15% Spectinomycin Hydrochloride na Lincomycin Hydrochloride Ifu ya Soluble

Pharmacodynamic damamycin ni antibiyotike ya aminoglycoside, kandi igira ingaruka zidakabije kuri bacili zitandukanye za garama-mbi, nka escherichia coli, salmonella, shigella, proteus nibindi. Irumva streptococcus, pneumococcus, epidermidis staphylococcus na mycoplasma zimwe na zimwe (nka mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, nibindi). Ahanini ntabwo yunvikana na virusi ya streptococcus na staphylococcus aureus. Ubusanzwe irwanya pseudomonas aeruginosa na treponema. Bagiteri zo munda zirwanya cyane megamycine, ariko ntizigaragaza guhangana na streptomycine. Lincomycin ifite ibikorwa byiza bya antibacterial kurwanya bacteri za anaerobic, nka clostridium, peptococcus, peptostreptococcus, clostridium tetanus, clostridium perfringens na actinomyces nyinshi. Lincomycine ikora cyane kuri 50s subunit ya bagiteri ya ribosomes, igira ingaruka kuri synthesis ya proteyine ibuza kwagura urunigi rwa peptide.

Pharmacokinetics 7% gusa ya lincomycine yakirwa nyuma yubuyobozi bwimbere, ariko ikomeza kwibanda cyane mumitsi yigifu. Imyunyungugu ya tissue yibiyobyabwenge iri munsi yububiko bwa serumu. Ntibyoroshye kwinjira mumazi ya cerebrospinal fluid cyangwa ijisho, kandi igipimo cyo guhuza poroteyine ya plasma ntabwo kiri hejuru. Ibiyobyabwenge byinshi bisohoka muyungurura glomerular muburyo bwumwimerere. Bioavailable ya lincomycine ni 30% ~ 40% hamwe no kwinjirira nabi mubuyobozi bwo munwa. Igipimo cyo kwinjiza hamwe nubunini bwa lincomycine bishobora kugabanuka no kugaburira bivanze. Inkoko zahawe 50mg yiki gicuruzwa (zishonga mumazi yo kunywa) kuri kg yuburemere bwumubiri iminsi 7. Mugihe c'ikizamini, plasma lincomycine yageze kuri 0.14 μ g / ml, mugihe daguanmycine yibanze cyane. Nyuma yiminsi 7 yikizamini, yarenze 0.1μg / ml.