Pharmacodynamic lincomycin ni iyitwa antibiotique ya lincoamine, ni bacteriostatike, bagiteri zoroshye zirimo staphylococcus aureus (harimo na penisiline irwanya penisiline), streptococcus, pneumococcus, bacillus anthracis, erysipelas suis, mycoplasma suis, mycoplasma suis, mycoplasma suis synovialis), leptospirose na bagiteri ya anaerobic (nka clostridium difficile, clostridium tetanus, clostridium percapsulatus na actinomyces nyinshi). Ikora cyane cyane kuri 50s subunit ya bagiteri ya ribosome, kandi ikagira antibacterial muguhagarika kwaguka kwurunigi rwa peptide no kugira ingaruka kuri synthesis.
Kwinjira byihuta nyuma yo guterwa inshinge, hamwe no gutera inshinge imwe ya 11mg / kg mu ngurube hamwe n’amaraso ya 6.25μg / ml. Igipimo cya plasma protein gihuza cyari 57% - 72%. Ikwirakwizwa cyane muri vivo, hamwe nubunini bugaragara bwo gukwirakwiza 2.8 l / kg mu ngurube. Ikwirakwizwa cyane mumazi atandukanye yumubiri hamwe nuduce (harimo amagufwa), muribwo ubwinshi bwumwijima nimpyiko aribwo hejuru, kandi kwibumbira mumiti ya tissue bikubye inshuro nyinshi ugereranije na serumu mugihe kimwe. Irashobora kwinjira mu gitereko, ariko ntibyoroshye kwinjira mu nzitizi y'amaraso n'ubwonko, kandi biragoye kugera ku buryo bunoze bw'imiti mu mazi ya cerebrospinal fluid iyo habaye umuriro. Irashobora gukwirakwizwa ku mata, kandi kwibumbira mu mata ni kimwe no muri plasma. Igice c'ibiyobyabwenge gikoreshwa mu mwijima, kandi imiti hamwe na metabolite yayo isohoka binyuze mu mara, inkari n'amata. Gusohora mu ntebe birashobora gutinda iminsi myinshi, bityo bigira ingaruka mbi kuri mikorobe yangiza amara.
1. Iyo ihujwe na gentamicin, igira ingaruka zingirakamaro kuri bagiteri-nziza ya bagiteri nka staphylococcus na streptococcus.
2. Iyo uhujwe na aminoglycoside na antibiotike ya polypeptide, birashobora kongera ingaruka zo guhagarika imitsi ya neuromuscular. Ufatanije na erythromycine igira ingaruka zo kurwanya, kubera ko urubuga rwibikorwa ari kimwe, kandi erythromycine ifitanye isano ikomeye na 50s subunit ya bacteri ribosomes kurusha iki gicuruzwa.
3. Ntigomba guhuzwa n'imiti igabanya ubukana ibuza peristaliste yo munda kandi irimo ibumba ryera. 4. Hano ntaho bihuriye na kanamycin, neomycine, nibindi.
Antibiyotike ya Lincoamine. Indwara ya bagiteri nziza yanduye, irashobora kandi gukoreshwa muri treponemose na mycoplasma nizindi ndwara.
Gutera inshinge: Igipimo kimwe, 0.0165 ~ 0.033ml kuri 1 kg uburemere bwumubiri kumafarasi ninka, 0.033ml yintama ningurube, rimwe kumunsi; 0.033ml yimbwa ninjangwe, kabiri kumunsi, muminsi 3 kugeza 5.
Gutera inshinge birashobora gutera impiswi yigihe gito cyangwa intebe yoroshye. Nubwo bidasanzwe, ingamba zikenewe zigomba gufatwa kugirango birinde umwuma niba bibaye.
