10% Gutera inshinge

Icyuma cya Pharmacodynamic nikintu cyingenzi cya hemoglobine na myoglobine. Hemoglobine ni yo itwara ogisijeni nyamukuru mu maraso atukura. Myoglobin niho ingirabuzimafatizo zibika ogisijeni kugira ngo zifashe kuyiha imitsi mu gihe cy'imyitozo. Byinshi mu misemburo nibintu bigira uruhare muri cycle ya tricarboxylic irimo fer cyangwa imikorere gusa imbere yicyuma. Kubwibyo, usibye kwihuta kwa synthesis ya hemoglobine, ibimenyetso bifitanye isano no kubura ibyuma bya tissue hamwe nigabanuka ryibikorwa byimisemburo irimo fer, nko kudindira gukura, imyitwarire idasanzwe, hamwe nubushobozi bwumubiri, birashobora gukosorwa buhoro buhoro nyuma yinyongera yibyuma bikenerwa ninyamaswa zabuze fer. Icyuma cya Pharmacokinetic cyo guterwa cyinjizwa vuba kuruta icyuma cyo mu kanwa; nyuma yo guterwa inshinge dextran, icyuma cyamaraso cyageze kumasaha 24-48, kandi molekile yayo nini. Yakuwe mu mitsi ya lymphatike hanyuma yimurirwa mu maraso, maze umuvuduko w'amaraso wiyongera buhoro; nyuma yo guterwa inshinge cyangwa imitsi yinjira mumaraso, ni fagocytic kandi ibora fer na dextran na sisitemu ya selile monagile. Nyuma yo kwinjizwa, ioni ya fer ihindurwamo ion ferric na ceruloplasmin mumaraso, hanyuma igahuza na reseptor reseptor, ikinjira mu ngirabuzimafatizo ya pinocytose ya selile hematopoietic selile, cyangwa ikegeranya muburyo bwa ferritine cyangwa hemosiderine mumwijima, impyiko, igufwa ryamagufa hamwe nubundi buryo bwa selile fagocytique. Igipimo cya poroteyine gihuza cyane na hemoglobine, ariko kiri munsi ya myoglobine, enzymes na poroteyine zitwara ibyuma, ndetse na ferritine cyangwa hemosiderine.