Pharmacodynamics flufenicol ni antibiyotike yagutse.
Bya aminool, bacteriosuppressor, kandi ikora muguhuza na ribosome 50s subunit kugirango ibuze synthesis ya proteine za bagiteri. Ifite ibikorwa bikomeye bya antibacterial kurwanya bagiteri zitandukanye-nziza na bagiteri-mbi. Pasteurella hemolyticus, pasteurella multocida na actinobacillus suis pleuropneumoniae bumvaga cyane flufenicol. Muri vitro, ibikorwa bya mikorobe ya flufenicol irwanya mikorobe nyinshi birasa cyangwa birakomeye kuruta ibya sulfenicol, na bagiteri zimwe na zimwe zirwanya aminol bitewe na acetylation, nka escherichia coli na klebsiella pneumoniae, zirashobora kuba zumva flufenicol.
Ikoreshwa cyane cyane mu ndwara ziterwa na bagiteri z'ingurube, inkoko n'amafi ziterwa na bagiteri zoroshye, nk'indwara z'ubuhumekero z'inka n'ingurube ziterwa na pasteurella hemolyticus, pasteurella multocida na actinobacillus pleuropneumoniae. Tifoyide na paratyphoide iterwa na salmonella, kolera yinkoko, dysentery yinkoko yera, colibacillose, nibindi.; amafi pasteurella, vibrio, staphylococcus aureus, hydroomonas, enteritis nizindi bagiteri ziterwa na bagiteri y’amafi septicemia, enteritis, erythroderma na vuba.
Pharmacokinetics flufenicol yinjizwa vuba nubuyobozi bwimbere, kandi kwibanda kumiti birashobora kugerwaho mumaraso nyuma yisaha 1, kandi umuvuduko wamaraso urashobora kugerwaho mumasaha 1 kugeza kuri 3. Bioavailability irenze 80%. Flufenicol ikwirakwizwa cyane mu nyamaswa kandi irashobora kurenga inzitizi y'amaraso n'ubwonko. Isohoka cyane cyane mu nkari muburyo bwumwimerere no muke muke mumyanda.
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2. Irashobora kurwanya ibikorwa bya bagiteri yica penisiline cyangwa aminoglycoside, ariko ntabwo byagaragaye mubikoko.
Antibiyotike ya Amidoalcool, yunvikana cyane na Pasteurella hemolyticus, Pasteurella multocida na actinobacillus pleuropneumoniae, ikoreshwa mu kwandura Pasteurella na Escherichia coli.
Gutera inshinge: ikinini kimwe, kuri 1 kg ibiro byumubiri, 0.2ml yinkoko, 0.15 ~ 0.2ml yintama ningurube, 0.075 ~ 0.1ml kumafarasi ninka. Rimwe buri masaha 48, kabiri bikurikiranye. Amafi 0.005 kugeza 0.01ml rimwe kumunsi.
1.Ibicuruzwa bifite ingaruka zimwe na zimwe zo gukingira indwara iyo bikoreshejwe birenze urugero rwasabwe.
2. Ifite uburozi bw'inda, kandi igomba gukoreshwa ubwitonzi mugihe utwite ndetse n'amatungo yonsa.
1. Igihe cyo gutera inkoko kirabujijwe.
2. Inyamaswa zifite ubudahangarwa bukabije cyangwa igihe cyo gukingirwa zigomba kubuzwa.
3. Inyamaswa zifite impyiko zigomba kugabanywa neza cyangwa igihe kinini cyo kuyobora.
