75% Ifumbire ya Sulfachlorpyridazine Ifu ya Sodium

Iki gicuruzwa gifite ingaruka zikomeye zo guhagarika kuri bagiteri nyinshi nziza kandi mbi. Indwara ya bacteri yunvikana kumiti ya sulfonamide ntishobora gukoresha aside folike mubidukikije, irashobora gukoresha aside p-aminobenzoic na dihydropteridine, ikoresheje synthase ya bacteri dihydrofolate kugirango ikomatanye tetrahydrofolate, tetrahydrofolate ikora muri synthesis ya purine, nucleoside ya thymine igira uruhare runini muguhana kwa karubone. Imiti ya sulfa isa nuburyo bwa acide p-aminobenzoic, kandi irashobora guhangana na p-aminobenzoic aside ya dihydrofolate synthetase muri bagiteri, ikabuza synthesis ya dihydrofolate, amaherezo ikagira ingaruka kuri synthesis ya acide nucleique, ikanabuza gukura no kubyara kwa bagiteri. Igikorwa cyimiti ya sulfanilamide irashobora kurwanya imiti ishobora guhinduranya aside amine benzoic, nka procaine na tetracaine. Byongeye kandi, ibicuruzwa byangiza ibibyimba birashobora kandi gutanga ibintu byingenzi kugirango imikurire ya bagiteri, kandi bigira ingaruka mbi kuri sulfonamide. Trimethoprim ni antibacterial synergiste ibuza ibikorwa bya reductase ya dihydrofolate. Gukomatanya byombi birashobora kubyara imbaraga zo kongera imbaraga za antibacterial.