Pharmacodynamics ceftiofur ni class -lactam icyiciro cyimiti ya antibacterial, hamwe na bagiteri nini ya bagiteri yica udukoko, ifasha kurwanya bagiteri-nziza na bagiteri-mbi (harimo β - lactamase itanga bagiteri). Uburyo bwa antibacterial nuburyo bwo guhagarika synthesis yurukuta rwa bagiteri kandi biganisha ku rupfu rwa bagiteri. Bagiteri yunvikana cyane ni pasteurella multiplex, pasteurella hemolyticus, actinobacillus pleuropneumoniae, salmonella, escherichia coli, streptococcus, staphylococcus, nibindi. Pseudomonas aeruginosa, irwanya enterococcus. Ibikorwa bya antibacterial yiki gicuruzwa birakomeye kuruta ibya ampisilline, kandi ibikorwa byo kurwanya streptococcus birakomeye kuruta fluoroquinolone.
Pharmacokinetics ceftiofur yakirwa vuba kandi henshi ninshinge zo mu nda ndetse no munsi yubutaka, ariko ntishobora kurenga inzitizi yamaraso. Ubwinshi bwibiyobyabwenge nibwinshi mumaraso nuduce, kandi imbaraga zamaraso zigumaho igihe kirekire. Metabolite ikora desfuroylceftiofur irashobora gukorerwa mumubiri, hanyuma igahinduka mubicuruzwa bidakora bisohoka mu nkari no mumyanda.
ant-antibiyotike ya lactam. Ikoreshwa cyane mu kuvura indwara za bagiteri z’amatungo n’inkoko. Nka bagiteri zandurira mu myanya y'ubuhumekero hamwe n'inkoko escherichia coli, kwandura salmonella.
Ceftiofur irakoreshwa. Gutera inshinge: Igipimo kimwe, 1,1- 2,2mg kuri 1 kg ibiro byumubiri ku nka, 3-5mg ku ntama ningurube, 5mg ku nkoko nimbwa, rimwe kumunsi iminsi 3.
Gutera insimburangingo: inkoko zumunsi-1, 0.1mg kuri buri kibaba.
(1) Irashobora gutera gastrointestinal flora guhungabana cyangwa kwandura kabiri.
(2) Hariho nephrotoxicity.
(3) Ububabare bwigihe gito bushobora kubaho.
(1) Koresha ubu.
(2) Igipimo kigomba guhindurwa kubinyamaswa zidafite impyiko.
(3) Abantu bumva cyane antibiyotike ya beta-lactam bagomba kwirinda guhura nibicuruzwa kandi bakirinda guhura nabana.
